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Profhilo vs. Radiesse vs. Sculptra: Which Skinbooster Treatment is Right for You?

When it comes to non-surgical skin rejuvenation treatments, Profhilo, Radiesse, and Sculptra are among the top choices. Each treatment offers unique benefits and targets different skin concerns. Understanding their differences can help you decide which one is right for your needs.

Non-surgical Skinbooster in Dubai Radiesse Sculptra

History and Background

Profhilo SkinBooster

What is Profhilo?

Profhilo is a revolutionary anti-aging treatment that uses a unique formulation of hyaluronic acid (HA). Unlike traditional dermal fillers that add volume to specific areas, Profhilo spreads evenly beneath the skin to provide deep hydration and stimulate the natural production of collagen and elastin. This results in overall skin improvement, making it firmer, smoother, and more youthful-looking.


Profhilo was developed by IBSA, a multinational pharmaceutical company based in Switzerland. It was first introduced in Italy in 2015 and quickly gained popularity across Europe due to its innovative approach to skin rejuvenation. Profhilo is now widely used globally and is especially popular in countries like the UK and UAE.

What Concerns Does Profhilo Treat?

Profhilo is ideal for treating:

  • Fine lines and wrinkles

  • Loss of skin elasticity

  • Crepey skin on the face, neck, décolletage, and hands

  • Dull and dehydrated skin

Radiesse SkinBooster

What is Radiesse?

Radiesse is a dermal filler that contains calcium hydroxylapatite (CaHA) microspheres suspended in a water-based gel. Unlike hyaluronic acid fillers, Radiesse not only provides immediate volume and lift but also stimulates the body’s natural collagen production over time, leading to longer-lasting results.


Radiesse was approved by the FDA in 2006 for the correction of moderate to severe facial wrinkles and folds, such as nasolabial folds. It was developed by Merz Pharmaceuticals, a company with a long history in the field of aesthetic medicine. Over the years, Radiesse has expanded its applications beyond facial rejuvenation to include hand augmentation and other off-label uses.

What Concerns Does Radiesse Treat?

Radiesse is effective for:

  • Deep facial wrinkles and folds

  • Facial volume loss and contouring, particularly in the cheeks and jawline

  • Hand rejuvenation

  • Nasolabial folds and marionette lines

Sculptra SkinBooster

What is Sculptra?

Sculptra is a biostimulatory filler made of poly-L-lactic acid (PLLA), a synthetic substance that stimulates collagen production. Unlike other fillers that provide immediate results, Sculptra works gradually, with results becoming more noticeable over several months as collagen is rebuilt in the treated areas. This makes Sculptra ideal for patients seeking a natural-looking, long-term improvement.


Sculptra was originally approved by the FDA in 2004 for the treatment of facial lipoatrophy (loss of fat beneath the skin) in HIV patients. It was developed by Dermik Laboratories, a division of Sanofi-Aventis. Its success in restoring facial volume led to its widespread use in cosmetic dermatology for anti-aging purposes. Sculptra is now a popular choice for non-surgical facial rejuvenation worldwide.

What Concerns Does Sculptra Treat?

Sculptra is used to address:

  • Deep facial wrinkles and folds

  • Significant volume loss in areas such as the cheeks, temples, and jawline

  • Overall facial contouring and volumization

  • Some off-label uses include body contouring

Profhilo Radiesse Sculptra Injections Dubai

Detailed Comparison - Radiesse vs. Sculptra vs. Profhilo Skinbooster

Composition and Mechanism of Action

Profhilo: Contains pure hyaluronic acid, which spreads evenly beneath the skin to hydrate and improve skin elasticity. It stimulates collagen and elastin production, resulting in firmer and smoother skin.

Radiesse: Composed of calcium hydroxylapatite (CaHA) microspheres suspended in a gel carrier. Radiesse provides immediate volume and stimulates the body’s natural collagen production over time.

Sculptra: Made of poly-L-lactic acid (PLLA), Sculptra works by stimulating collagen production to restore facial volume gradually. It provides a natural-looking improvement over several months.

Treatment Areas

Profhilo: Ideal for treating the face, neck, décolletage, and hands. It’s especially effective for areas with fine lines and crepey skin.

Radiesse: Commonly used for facial contouring, including the cheeks, jawline, and nasolabial folds. It’s also used for hand rejuvenation.

Sculptra: Suitable for volumizing larger areas of the face, such as the temples, cheeks, and jawline. It’s also used for body contouring in some cases.

Duration of Results

Profhilo: Results are typically visible after two sessions, with effects lasting up to six months.

Radiesse: Immediate results are noticeable, with continued improvement over time. Effects can last up to a year or more.

Sculptra: Gradual improvement is seen over several months, with results lasting up to two years after a full treatment course.

Treatment Process

Profhilo: Involves two sessions spaced four weeks apart. The treatment is quick, with minimal downtime.

Radiesse: Usually requires a single session, but touch-ups may be needed. There is minimal downtime.

Sculptra: Typically requires three sessions over a few months. Minimal downtime is expected, but multiple sessions mean a longer overall treatment period.

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Pre and Post Treatment Recommendations

Pre-Treatment Recommendations:

Consultation: Schedule a consultation with a qualified practitioner to discuss your goals and determine the best treatment for you.

Avoid Blood Thinners: Avoid taking blood thinners like aspirin, ibuprofen, and certain supplements for at least a week before the treatment to reduce the risk of bruising.

Hydrate: Drink plenty of water in the days leading up to your treatment to ensure your skin is well-hydrated.

Post-Treatment Recommendations:

Avoid Sun Exposure: Limit sun exposure and use sunscreen to protect your skin after treatment.

Avoid Alcohol and Strenuous Exercise: Avoid alcohol and strenuous exercise for 24 hours post-treatment to minimize swelling and bruising.

Follow Aftercare Instructions: Follow any specific aftercare instructions provided by your practitioner to ensure optimal results.

Benefits and Concerns


Profhilo Benefits:

Deep Hydration: Profhilo contains one of the highest concentrations of hyaluronic acid on the market, providing intense hydration to the skin. This helps to improve skin texture and gives a glowing, youthful appearance.

Skin Remodeling: Unlike traditional fillers, Profhilo spreads evenly beneath the skin and works on remodeling aging and sagging tissues. It stimulates the production of collagen and elastin, resulting in firmer and more elastic skin.

Natural Results: Profhilo does not add volume in a localized area but rather improves the overall quality of the skin, ensuring natural-looking results without altering facial contours.

Quick Treatment: The procedure involves two sessions spaced four weeks apart, making it a relatively quick treatment with minimal downtime.

Versatility: Profhilo can be used on various areas such as the face, neck, décolletage, and hands, making it a versatile treatment for overall skin rejuvenation.


Temporary Results: The results of Profhilo last up to six months, which means maintenance treatments are required to sustain the benefits.

Not for Deep Wrinkles: While Profhilo is excellent for hydration and improving skin quality, it may not be sufficient for treating very deep wrinkles or significant volume loss.


Radiesse Benefits:

Immediate Volume: Radiesse provides immediate results, offering instant volume and correction of facial wrinkles and folds. This makes it an excellent choice for those seeking quick improvements.

Collagen Stimulation: In addition to immediate volume, Radiesse stimulates the body’s natural collagen production. This dual-action approach means that the results improve over time as new collagen is formed.

Long-Lasting Results: The effects of Radiesse can last up to a year or more, making it a cost-effective option for long-term facial rejuvenation.

Versatile Applications: Radiesse is effective for facial contouring, including enhancing the cheeks, jawline, and nasolabial folds. It is also FDA-approved for hand rejuvenation, addressing volume loss in the hands.


Potential for Lumps: If not injected properly, Radiesse can sometimes result in lumps or uneven texture under the skin.

Not Easily Reversible: Unlike hyaluronic acid fillers, which can be dissolved if needed, Radiesse is not easily reversible. This makes it crucial to have the treatment performed by an experienced practitioner.

Possible Side Effects: Common side effects include swelling, bruising, and redness at the injection site. In rare cases, there may be more serious complications such as infection.


Sculptra Benefits:

Gradual and Natural-Looking Results: Sculptra works gradually by stimulating collagen production, leading to subtle, natural-looking improvements over time. This approach helps avoid the overfilled appearance that can sometimes occur with other fillers.

Long-Lasting Effects: The results of Sculptra can last up to two years after a full treatment course, providing long-term benefits with minimal maintenance.

Significant Volume Restoration: Sculptra is ideal for patients needing substantial volume restoration, such as those with deep wrinkles, significant facial volume loss, or hollow areas.

Body Contouring: In addition to facial rejuvenation, Sculptra is also used off-label for body contouring, including the correction of cellulite and volume loss in areas like the buttocks.


Multiple Sessions Required: Sculptra typically requires three sessions spaced a few months apart to achieve optimal results. This means a longer overall treatment period compared to other fillers.

Delayed Results: Because Sculptra works gradually, patients may not see noticeable improvements until several months after the initial treatment.

Aftercare Requirements: Proper aftercare is essential with Sculptra to ensure even distribution of the product. This includes massaging the treated areas several times a day for the first few days after treatment.

Risk of Nodules: There is a risk of developing small nodules or lumps under the skin, particularly if the product is not massaged properly or injected incorrectly.

Skin Rejuvenation Dubai


1. What is the main difference between Profhilo, Radiesse, and Sculptra?

Profhilo hydrates and remodels the skin with hyaluronic acid, Radiesse provides immediate volume with calcium hydroxylapatite, and Sculptra gradually restores volume with poly-L-lactic acid.

2. How long do the results of each treatment last?

Profhilo lasts up to six months, Radiesse up to a year or more, and Sculptra up to two years.

3. Which treatment has the least downtime?

Profhilo and Radiesse both have minimal downtime, while Sculptra may require a longer overall treatment period due to multiple sessions.

4. Can these treatments be combined?

Yes, depending on your needs, a practitioner can recommend a combination of treatments for optimal results.

5. Are there any side effects or risks associated with these treatments?

Common side effects include swelling, bruising, and redness at the injection site. Serious risks are rare but can include infection or allergic reactions.

6. How do I choose the right treatment for my skin type and concerns?

Consult with a qualified practitioner who can assess your skin type and concerns to recommend the best treatment.

7. What is the cost comparison for Profhilo, Radiesse, and Sculptra?

Costs can vary based on location and provider. Generally, Profhilo and Radiesse are similarly priced per session, while Sculptra may be more expensive due to multiple sessions.

8. How many sessions are required for optimal results?

Profhilo typically requires two sessions, Radiesse usually one session, and Sculptra around three sessions for optimal results.

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Choosing between Profhilo, Radiesse, and Sculptra depends on your individual skin concerns and desired outcomes. Each treatment offers unique benefits, from immediate volume to gradual collagen stimulation. Consult with a professional at EDEN AESTHETICS Clinic to determine the best treatment plan tailored to your needs. Contact us today to schedule your consultation and take the first step towards rejuvenated skin.

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